Foam granulation is a novel technique that promises better distribution of the granulating system and better properties of the produced tablets. Foam binders have high spread-to-soak ratio, because of this binders are coated on to particles rather than soaked leading to less usage of binder. Many approved non-ionic, polymeric excipients are also suitable foaming agents. Foam technology has been proven to scale very easily for both immediate release and matrix controlled-release products. The technology also uses less water per granulation, which means less drying time and less impact on the environment. This technique is helpful for highly and poorly water soluble drugs and prevents over granulation and wetting. Orally dissolving tablets (ODT) provides a patient compliance for patients swallowing difficulties i.e., mainly pediatrics’ and Geriatric’s. Amlodipine besylate (ADB) is an anti-hypertensive and it is also used in many coronary artery diseases. In the present study ADB is formulated into a fast dissolving tablet using two super disintegrates such as croscarmellose sodium (CCS), fenugreek mucilage at various concentrations. F2 formulation with 10% concentration of fenugreek mucilage (natural) showed better results than synthetic.
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